FROM THE NEW YORK TIME — PRINTED DAILY

(J. Harris: So our immediate area is currently in a “low” transmission area and if you are vaccinated you might leave off your mask unless you were in a crowed, airless, spooky crowd.)

HOW DOES CDC DETERMINE DANGEROUS TRANSMISSION RISK?

The Netherlands plans a partial lockdown regardless of vaccination status.

”…It is the first recent lockdown affecting all people — whether vaccinated or not — in Western Europe, and it comes as the Netherlands registered 16,364 new cases on Thursday. That figure, a level not seen since early in the pandemic, was a 33 percent rise over the new cases registered a week earlier…Starting on Saturday, restaurants, bars and cafes in the country will have to close at 7 p.m. Sporting events will be held without spectators. Residents will not be allowed to invite more than four guests into their homes. And social distancing rules will be reinstated, though stores that sell essentials will remain open…About 76 percent of the country’s population is fully vaccinated against the coronavirus, according to Our World in Data.

Austria is likely to order a lockdown for unvaccinated people, its chancellor warns.

”…“The situation in Austria and other European countries is serious,” Mr. Schallenberg said in a statement, noting that hospital intensive care units were filling up faster than expected…The Austrian government said last week that it would bar people who are not fully vaccinated from entering places like restaurants and hair salons; that measure took effect on Monday. A lockdown like the one Mr. Schallenberg warned about would be much more restrictive…“With a vaccination, we protect not only ourselves, but also our friends, family and colleagues,” he said, adding, “It is simply our responsibility to protect the people of our country.”

Association of Sleep-Related Hypoxia With Risk of COVID-19 Hospitalizations and Mortality in a Large Integrated Health System

Results of this case-control study revealed that SDB and sleep-related hypoxia were not associated with increased SARS-CoV-2 positivity; however, once patients were infected with SARS-CoV-2, sleep-related hypoxia was an associated risk factor for detrimental COVID-19 outcomes. Strategies to better discern sleep apnea-specific hypoxic stress are needed, such as use of sleep apnea–related hypoxic burden as a more sensitive biomarker of sleep apnea–related hypoxia, as the latter is recognized to be associated with increased cardiovascular mortality.¹⁴ Furthermore, understanding how sleep-related hypoxia may influence vaccine efficacy as well as elucidating underlying hypoxic mechanisms portending more severe COVID-19 disease and mortality are salient future directions. The current findings set the stage for interventional studies to identify whether early, effective PAP or supplemental oxygen administration in those with high nocturnal hypoxic physiological stress improves COVID-19 outcomes. If sleep-related hypoxia indeed translates to worse COVID-19 outcomes, risk stratification strategies should be implemented to prioritize early allocation of COVID-19 therapy to this subgroup of patients.

FROM BECKER:

1. 10 states challenge healthcare worker vaccination mandate

2. Walmart heir Alice Walton wants to reform healthcare

FROM HOPKINS

1. What Would the Public Health Experts Do? STAT Asked 28 About Their Holiday Plans Amid Covid-19 (STAT News) To try to gauge where things stand, we asked a number of infectious diseases experts about the risks they are willing to take now, figuring that their answers might give us a sense of whether we’re making our way out of the woods. Their responses signal some progress — but not as much, to be honest, as we had hoped.  The 28 people who replied to our most recent questionnaire are public health experts, epidemiologists, immunologists, and virologists. Most of the questions required a “Yes” or “No” answer; many also could be answered “Masked”, shorthand for “Yes, I’d do this, but I would wear a mask while doing it.” Some questions elicited a “Maybe” or two. In many cases, the answers came with caveats.

2.  Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic (JAMA Internal Medicine) In this cross-sectional analysis of 26 823 adults from the population-based French cohort during the COVID-19 pandemic, self-reported COVID-19 infection was associated with most persistent physical symptoms, whereas laboratory-confirmed COVID-19 infection was associated only with anosmia. Those associations were independent from self-rated health or depressive symptoms. Findings suggest that persistent physical symptoms after COVID-19 infection should not be automatically ascribed to SARS-CoV-2; a complete medical evaluation may be needed to prevent erroneously attributing symptoms to the virus.

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