(J. Harris: Ken Belson has written several stories about Marshall and maintains ties to our community. He knows a lot about football — and Covid. Why or why couldn’t Bart Starr been as stupid and careless as is Rodgers?!!!)

We’re close to the end of the pandemic phase’

”…”I think that we’re close to the end of the pandemic phase of this virus, and we’re going to enter a more endemic phase,” said Dr. Gottlieb, former FDA commissioner and current Pfizer board member…..This delta virus is going to play out through the country,” Dr. Gottlieb said. “There’s not much we’re going to be able to do at this point to interrupt it. We’ve seen the South be engulfed with the infection and it’s recovered. The reality is this delta infection is going to capture most people who remain unvaccinated at this point.”…He highlighted the recent approval of Pfizer’s COVID-19 vaccine for young children and the development of two potential COVID-19 antivirals as the beginning of the end of the virus’s pandemic status….

“We’ve always said that two [ONE]of the events that would demarcate the end of this pandemic was being able to vaccinate our children,” Dr. Gottlieb said. “We’re now able to do that down to age 5, and [?2} also having a widely available or orally accessible drug that could treat coronavirus at home to prevent people from being hospitalized or dying,” he said, referring to Merck and Pfizer’s experimental antiviral pills.

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm

(J. Harris: Study discusses pregnance and Covid vaccination.)

”…The balance of risk favours COVID-19 vaccination in pregnancy, particularly to avoid severe maternal infection or preterm or caesarean birth. These data should be used to address and avoid vaccine hesitancy driven by knowledge gaps…’

Transmission of SARS-CoV-2 After COVID-19 Screening and Mitigation Measures for Primary School Children Attending School in Liège, BelgiumDespite the implementation of several mitigation measures, the incidence of COVID-19 among children attending primary school in this study was comparable to that observed among teachers and parents. Transmission tree reconstruction suggests that most transmission events originated from within the school. Additional measures should be considered to reduce the transmission of SARS-CoV-2 at school, including intensified testing.

The partisan [political] gap in Covid deaths has grown larger.

An Unsolved Mystery: Why Do More Men Die of Covid-19?

(J. Harris: Interesting article that is worth the time to read.)

”…Yale University researchers noted that there are well-established differences in immune responses to infections between men and women. Diseases like tuberculosis are more common among men, for example, and men tend to have higher viral loads of hepatitis C virus and H.I.V. The same researchers found differences in men’s and women’s immune responses to Covid-19. Men with Covid-19 had higher blood levels of inflammatory proteins that regulate immune responses, for example. This could lead to an overexuberant immune response to the coronavirus….Other researchers argue that hormonal factors might be at play. Testosterone may tamp down men’s immune response, while estrogen may play a role in women’s tendency to have more immune B cells, which produce antibodies. Estrogen may inhibit the kind of immune cells that are thought to play a role in myocarditis…”

Assessment of Cognitive Function in Patients After COVID-19 Infection

”…In this study, we found a relatively high frequency of cognitive impairment several months after patients contracted COVID-19. Impairments in executive functioning, processing speed, category fluency, memory encoding, and recall were predominant among hospitalized patients. The relative sparing of memory recognition in the context of impaired encoding and recall suggests an executive pattern. This pattern is consistent with early reports describing a dysexecutive syndrome after COVID-194 and has considerable implications for occupational, psychological, and functional outcomes. It is well known that certain populations (eg, older adults) may be particularly susceptible to cognitive impairment after critical illness5; however, in the relatively young cohort in the present study, a substantial proportion exhibited cognitive dysfunction several months after recovering from COVID-19. The findings of this study are generally consistent with those of research on other viruses (eg, influenza)…”

Regeneron COVID-19 antibody drug reduces infection risk 82% in clinical trial

REGEN-COV is a combination of the monoclonal antibodies casirivimab and imdevimab. In November 2020, it received FDA emergency use authorization. The FDA revised its emergency use authorization July 30, allowing the treatment to be used as a postexposure prophylaxis for COVID-19 in individuals who are at high risk for progression to severe COVID-19.

(J. Harris: This is an IV antibody cocktail that works. We also now have two new oral theuraputic drugs (Merck and Pfizer) that just came out. 




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