CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/25/2021

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/25/2021

Marshall News Messenger] Marion County to administer second round of vaccinations; Marshall to offer 400 shots this week

(J. Harris: Of course, these were gone almost immediately, most likely.)

Willingness to Pay for a COVID-19 Vaccine

(From Chile)

MORE SCHOOL/COVID CONSIDERATIONS CITED BY HOPKINS:

SCHOOL-BASED TRANSMISSION A study conducted by the University of Florida and the Florida Department of Health, published in JAMA, investigated the impact of student quarantine and testing protocols at K-12 schools in Alachua County, Florida. Data indicate that the COVID-19 incubation period in children is 6 to 7 days, shorter than the 4 to 5 days in adults. The county implemented 14-day self-quarantine for students exposed to known COVID-19 cases, and students were allowed to return to school early if they received a negative RT-PCR diagnostic test on Day 9 or later. The rationale for this program was that SARS-CoV-2 infection should be detectable by Day 9 and that students who tested negative could safely return to school the next day. Out of 799 students who received a negative test under this program, only 1 developed symptomatic disease after returning to school, and genomic data indicate that the student was actually infected through a different exposure than the one that prompted quarantine. The program to enable students to end their quarantine period early reduced the total number of missed school days by more than 30% without resulting in any additional transmission. This study provides evidence that schools can implement testing protocols to promote in-person learning while effectively mitigating transmission risk.

A study conducted by the US CDC COVID-19 Response Team and school and public health officials in Georgia, published in the CDC’s MMWR, found that half of school-associated cases initiated from teacher-to-teacher transmission and then spread from teachers to students. The researchers evaluated data from 24 days of in-person learning at elementary schools in a single school district, which included approximately 2,600 students and 700 staff. In total 9 clusters of cases were identified, involving 13 teachers, 32 students, and 18 additional instances of household transmission. Of the 31 school-associated cases, 15 were students who are believed to have been infected following transmission between teachers. Notably, all 9 of the school clusters “involved less than ideal physical distancing, and five involved inadequate mask use by students.” The “central” role of teachers in school-based transmission provides support for vaccinating teachers in order to mitigate transmission risk during in-person classes. Current US CDC guidance indicates that teachers need not be vaccinated before schools can reopen, but many teachers unions are calling for changes to existing guidance and policies that would prioritize teachers as essential workers in order to provide protection before resuming in-person learning. 

The origin and early spread of SARS-CoV-2 in Europe

“We see that under sustained risk of case migration from abroad, isolated cases were confirmed throughout Europe beginning in late January 2020 but did not immediately cause large outbreaks. Shortly after the first evidence of sustained within-region transmission in Italy, outbreaks in the rest of Europe also took hold.  …we only observe sustained outbreaks in other European regions after the onset of sustained within-region transmission in Italy. Finally, before the first border closures in Europe, we estimate the risk of new cases arising from within-region transmission to be within or exceeding the estimated range for the risk of new migration cases.”

(J. Harris: I think they mean that by the time they closed European borders, Covid was already in their countries and spread there as rapidly as it would have had they left the borders open. Long and complex article.)

CURRENT BECKER CITATIONS:

1.Johnson and Johnson’s single-shot COVID-19 vaccine is safe and prevented both hospitalizations and deaths in a large clinical trial, according to an FDA review. The vaccine was more than 85 percent effective at preventing severe illness and 66 percent effective at preventing moderate and severe disease four weeks after the shot. An external committee is set to meet Feb. 26 to recommend whether the FDA should grant the vaccine emergency authorization, reports The Washington Post.

2. A coronavirus variant found in California in December is more contagious than previously circulating forms of the virus, according to early research cited by The New York Times. The two cited studies have not been peer-reviewed, and researchers said they are unsure how this variant, known as B.1.427/B.1.429, compares to others circulating in the state in terms of their threat to public health.

J. Harris: My Norweigan housekeeper sent me a warning from a “Brand X” magazine  that some recipients of vaccines had later noticed lymph node swelling, presumably under the same arm that received the vaccine. The nodes subsided in a few days. I mention it now so that she continues to keep the table full at meal time. I’m reluctant to “waist away.”

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/24/2021

What are our local and county wide plans to help people get vaccinated? Who has the plan? When does it start. Only 2.2% of county people are vaccinated. The state average is 4.9% vaccinated. (Gregg 4.1%, Smith 6.0%).The vaccines are safe and work very well. The few people who sick despite having been vaccinated are rarely sick enough to require hospitalization! We are making progress, but locally, we are falling behind the rest of the area counties and the state. Encouragine and implementing vaccinations is now a LOCAL PROBLEM. Let’s get rolling. 

Good News from the CDC, cited by Hopkins:

“The US CDC reported 27.94 million total cases and 497,415 deaths. Daily incidence continues to fall sharply in the US, now down to fewer than 65,000 new cases per day—the lowest average since October 23, 2020…As daily COVID-19 incidence and mortality continue to decrease in the US, so do hospitalizations. According to data compiled by the COVID Tracking Project, current hospitalizations nationwide are down to 55,403, a decrease of 58% from the peak on January 6…The official CDC data track the number of new hospitalizations per day (ie, as opposed to current hospitalizations). New hospitalizations peaked on January 6, with an average of 16,536 per day. Since then, new daily hospitalizations have declined steadily, down to 6,417—a decrease of more than 60% from the peak. The current average is more than 20% less than the previous week.”

Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats

“…This manuscript describes a pilot study in which domestic cats and dogs were assessed for their susceptibility to infection. While neither species developed clinical disease in this study, cats shed infectious virus for up to 5 d and infected naive cats via direct contact, while dogs do not appear to shed virus. Cats that were reinfected with SARS-CoV-2 mounted an effective immune response and did not become reinfected. These studies have important implications for animal health and suggest that cats may be a good model for vaccine development.”

(J. Harris: Other studies mentioned in this article show dogs can also become infected and shed viruses.)

Cited by Becker’s:

1. Americans may still need to wear face masks in 2022, Anthony Fauci, MD, said during a Feb. 21 interview on CNN’s State of the Union. The director of the National Institute of Allergy and Infectious Diseases said the U.S. may reach “a significant degree of normality” by the end of 2021, but did not rule out the possibility of masks being needed next year.

2. The FDA issued an alert about the accuracy of pulse oximeters Feb. 19. The agency said pulse oximeter readings can be affected by multiple factors, including skin pigmentation, skin thickness, poor circulation, skin temperature, tobacco use and fingernail polish. 

HOPKINS SUGGESTS:

Smiths Detection’s BioFlesh system capable of detecting SARS-CoV-2 in the air

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 (J. Harris: Unfortunately some of the mutants are already circulating.)

VISUALIZING CASKETS FROM NEW YORK TO INDIANAPOLIS

By Debra Adams Simmons, HISTORY Executive Editor, (NATIONAL GEOGRAPHIC)

“How do you process a number as staggering as 500,000 COVID-19 deaths in the United States…The number is 25 percent more than the U.S. military death toll in World War II. It would be like imagining every person in a city the size of Atlanta had been lost. Or every postal service worker. This unimaginable number, 500,000, translates into 645 miles of caskets spread end to end…”

A Vaccination against the Pandemic of Misinformation

“Has our nation’s suboptimal education weakened the prefrontal cortex of our American brain, thus leaving us susceptible to false beliefs? Low educational attainment is a risk factor for Alzheimer’s disease and other forms of dementia, suggesting that high educational attainment is associated with fostering neuroanatomical conditions that protect our brain from the pathophysiologic changes of Alzheimer’s disease. This remarkable scientific finding supports the idea that high-quality education and science literacy physiologically and functionally strengthen the brain, protecting us from the threat of false beliefs during times of uncertainty and crisis.”

(J. Harris: This is a provocative Scientific American article of interest to educational advocates as well as to those who just can’t believe the number of modern Americans whose thoughtlessness, unmasked by the pandemic, might provoke Shakespear’s lament: “Lord what fools these mortals be…”)

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/23/2021

HELLO,

I am unaware of any current Vaccination Data. Should any current Harrison County vaccination information come your way, please pass it on. J. Harris

SARS-CoV-2 antibody seroprevalence in the general population and high-risk occupational groups across 18 cities in Iran: a population-based cross-sectional study

” In conclusion, the findings of this study imply that prevalence of seropositivity is likely to be much higher than the reported prevalence rates based on confirmed COVID-19 cases in Iran. Despite the high seroprevalence estimates in a few cities, the low overall prevalence estimates highlight the fact that a large proportion of the population in Iran is still uninfected. The similar seroprevalence estimates across high-risk occupations in this study could indicate that the currently applied infection control measures might be inadequate or not appropriately adhered to or enforced. As such, there is an urgent need for public health policies and adequate personal protective equipment among front-line workers to prevent the potential increase in patient load in hospitals across the country, especially during the second wave of infection.”

(J. Harris: Many don’t agree with all of the statistics in this study; however, it seems to present a good overall picture of Covid in Iran?)

ANOTHER LANCET  ARTICLE:

Anti-SARS-CoV-2 antibodies in healthy donor plasma pools and IVIG products

“These results suggest that plasma pools for fractionation might mirror the immunogenic status of the general population regarding SARS-CoV-2. Consequently, anti SARS-CoV-2 antibodies are being increasingly integrated into therapeutic IVIG products and, presumably, into intramuscular and subcutaneous immunoglobulin products. Since these products are indicated for immunodeficient patients and other therapeutic or prophylactic approaches, a close follow-up of the progression of the presence of anti-SARS-CoV-2 antibodies in both plasma pools and IgG products is recommended.”

(J. Harris: Treatment with serum products containing antibodies to Covid has been shown to be of therapeutic benefit, and by studying blood donors, the percentage of prior Covid infected individuals in selected populations can be closely estimated from various areas and Countries.)

Booster Shots Against Scary COVID Virus Variants Are In the Works

(J. Harris: Nice readable article on good vaccine progress toward updated formulations and boosters and discusses all the available vaccines, briefly.)

Association of the Timing of School Closings and Behavioral Changes With the Evolution of the Coronavirus Disease 2019 Pandemic in the US

“Given the uncertainty surrounding the severity and transmission dynamics of the disease, the decision to close schools in spring 2020 was reasonable. However, this analysis suggests that school closures did not play the only or even most important role in slowing the spread of the disease. Other, less harmful, means may be found in the future to effectively limit further spread of COVID-19.”

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/22/2021

J. Harris: The numbers are still lagging due to the weather related reporting difficulties.

Nevertheless, most Covid news is GOOD. I plan to help promote vaccinations over the next few months, and continued preventive measures, such as MASKS. Harrison County has many people who don’t or won’t wear masks. Recent visitors from Austin were incredulous that  many people were not wearing masks when out and about downtown. Stores did not check temperatures or insist that customers be masked in order to shop in their stores. Naturally, cautious people avoid shopping in Marshall if they can. We must remain vigilant and carefully evaluate the illness that the “Mutants” might cause now and in the future. It will be difficult to reach “herd immunity” when only 2.2% of Harrison County citizens have been vaccinated? 

The Pandemic Is Receding in the Worst Hotspots. Will It Last?

(J. Harris: Good NYT general article with brief world wide review of diminished Covid cases and why.)

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

(J. Harris: We saw a brief summary of this a couple of days ago. We also have a chart which is a new way to present data to the public with a medical article.)

“RESULTS

A total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P=0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.

CONCLUSIONS

Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19….”

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

“CONCLUSIONS

These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.

“Here Is What Happened To Me Six Months After Recovering From COVID-19

(J. Harris: Sequlae to a mild case of Covid in an understandably confused patient.)

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/20/2021

GOOD VACCINE NEWS FROM NYT FRI:

A batch of new data this week is giving us more insight into the effectiveness of vaccines and how to best distribute them. Let’s start with a few positive developments that could expand access to the Pfizer-BioNTech Covid-19 vaccine.
A new study in Israel found that the Pfizer vaccine was 85 percent effective after one shot, a finding that could lead some countries to delay the second shot in order to get more people vaccinated more quickly.The results echo research on the AstraZeneca vaccine, which has been shown to offer protection weeks after the first dose.A separate study published today suggested that the AstraZeneca vaccine was more effective when people received a second dose after three months, instead of six weeks.
The new findings lend ammunition to experts and governments, including that of Britain, which have advocated a “first dose first” strategy, which prioritizes giving as many people as possible an initial dose. But Dr. Fauci said that U.S. health officials were not willing to change their recommendations that all people receive two shots.
Pfizer and BioNTech also announced today that their vaccine can be stored at standard freezer temperatures for up to two weeks, rather than five days as recommended in their initial guidelines. Distribution of doses has been complicated by the requirement that the vaccines be stored at ultracold temperatures, and the change has the potential to expand the number of smaller pharmacies and doctors’ offices that can administer the vaccine.
Separately, new data from the Centers for Disease Control and Prevention found that the vaccines from Pfizer and BioNTech and Moderna were reassuringly safe and that side effects were rare. The agency examined nearly 14 million vaccinations and found nearly 7,000 reports of adverse events — including headaches, fatigue and muscle aches — and said that 91 percent of those cases were not serious.From Hopkins: Additional resources are available on our website.1. EMERGING VARIANTS A study published (preprint) by Harvard University examines the nasopharyngeal viral concentration in individuals infected with the B.1.1.7 SARS-CoV-2 variant…  The researchers found that infection with the B.1.1.7 variant lasted significantly longer than for other variants, with a mean duration of infection of 13.3 days for the B.1.1.7 variant, compared to 8.2 days for non-B.1.1.7 variants. While the duration of infection was longer for the B.1.1.7 variant, the peak viral concentration was similar between B.1.1.7 and non-B.1.1.7 variants.”SARS-CoV-2 Positivity on or After 9 Days Among Quarantined Student Contacts of Confirmed Cases  (In this study of a 9-day testing protocol for student contacts of confirmed COVID-19 cases in 1 Florida county, a reduction in loss of instructional time was found that was less than what would have occurred with 14-day quarantine. There was no evidence that an earlier return to school with a negative test result was linked with subsequent symptomatic illness. Had students returned to school before day 14 without testing on day 9 or thereafter, 8.2% of high school contacts would have returned to school with SARS-CoV-2 infection. These findings should be considered when evaluating the December 2020 CDC recommendation for a 10-day quarantine without testing or a 7-day quarantine with testing.Sequelae in Adults at 6 Months After COVID-19 Infection “In this cohort of individuals with COVID-19 who were followed up for as long as 9 months after illness, approximately 30% reported persistent symptoms. A unique aspect of our cohort is the high proportion of outpatients with mild disease…”(J. Harris: LONG HAULER ARTICLE, which includes many patients whose illness did not require hospitalization. A significant number of people were significantly improved by 9 months

.

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/19/2021

COVID-19 Cases Are Dropping Fast. Why?

“Four reasons: social distancing, seasonality, seroprevalence, and shots.”

(J. Harris: This is a readable, informative article. I’d add another reason cases are dropping: No one’s testing for Covid in many areas, including Texas.)

Experts Express Concern Over Airborne Spread of More Contagious Coronavirus

(J. Harris: Easy to read article makes you want to double mask with the mutants lurking about.)

Childhood Colds Do Not Prevent Coronavirus Infection, Study Finds

“The idea that having the snuffles a while back somehow protects you from SARS-CoV-2 infection has always left me cold, but it’s been a persistent urban legend throughout the pandemic,…Hopefully, this new paper will finally cool everyone down and put such thoughts into the freezer.”

(J. Harris: Good NYT summary of several articles. Having had lots of “colds” does not protect kids or adults from Covid infection. Several articles are reviewed.)

HOW LONG DOES IT TAKE MY VACCINE TO WORK:

HOPKINS SUGGESTIONS:

1. U.K. Gets Approval to Infect Healthy Volunteers in World’s First Coronavirus ‘Challenge Trial’ (Washington Post) Britain will become the first country to deliberately infect healthy volunteers with the coronavirus, now that the country’s ethics body has approved a “human challenge trial.”

The effort, funded by the British government, aims to accelerate scientific understanding of vaccines and treatments.

2. Scientists Call on C.D.C. to Set Air Standards for Workplaces, Now (New York Times) Nearly a year after scientists showed that the coronavirus can be inhaled in tiny droplets called aerosols that linger indoors in stagnant air, more than a dozen experts are calling on the Biden administration to take immediate action to limit airborne transmission of the virus in high-risk settings like meatpacking plants and prisons.

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/18/2021

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/18/2021

HELLO:
It seems we got lucky with the ice. Good!

Christus postpones weekend COVID-19 vaccine clinic in Longview

“Christus Good Shepherd Medical Center is postponing its planned vaccine hub clinic in Longview, scheduled for Saturday and Sunday, because of the winter storm….According to a statement Wednesday from Christus, those with Saturday appointments to receive their second dose of the vaccine will be rescheduled to the same time slot on March 5. Those with appointments Sunday to receive their first dose of the vaccine will be rescheduled to the same time slot March 7. Individuals do not need to take any action at this time.”

LONG HAUL CONSIDERATIONS:

1. Programs Help COVID Long Haulers Recover

(J. Harris: A general Webb, MD article easy to read, but with good references which includes #2 below which I believe we looked at in Jan. but which is extensive and worth a revisit) 

2. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

“At 6 months after acute infection, COVID-19 survivors were mainly troubled with fatigue or muscle weakness, sleep difficulties, and anxiety or depression. Patients who were more severely ill during their hospital stay had more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, and are the main target population for intervention of long-term recovery.”

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19

“Findings  In this randomized clinical trial that involved 240 hospitalized patients with moderate to severe COVID-19, a single dose of 200 000 IU of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay (median of 7.0 vs 7.0 days; unadjusted hazard ratio for hospital discharge, 1.07).”

Air Cleaners, HVAC Filters, and Coronavirus (COVID-19)

HOPKINS SUGGESTS:

1. Convalescent Plasma Treatment is Associated with Lower Mortality and Better Outcomes in High Risk COVID-19 Patients – Propensity Score Matched Case-control Study (International Journal of Infectious Diseases) A significantly lower mortality rate was observed in the group of patients treated with CP. Age, presence of cardiac insufficiency, active cancer, requirement of ventilator, and length of hospitalization were significantly increasing the risk of death in both groups. Our study shows, that CP brings better outcomes when administered in the earlier stage of high-risk COVID-19 disease.

2. The Coronavirus is Here to Stay — Here’s What that Means (Nature) But failure to eradicate the virus does not mean that death, illness or social isolation will continue on the scales seen so far. The future will depend heavily on the type of immunity people acquire through infection or vaccination and how the virus evolves. Influenza and the four human coronaviruses that cause common colds are also endemic: but a combination of annual vaccines and acquired immunity means that societies tolerate the seasonal deaths and illnesses they bring without requiring lockdowns, masks and social distancing.

Millions of Jobs Probably Aren’t Coming Back, Even After the Pandemic Ends (Washington Post) Millions of jobs that have been shortchanged or wiped out entirely by the coronavirus pandemic are unlikely to come back, economists warn, setting up a massive need for career changes and retraining in the United States.

3. Millions of Jobs Probably Aren’t Coming Back, Even After the Pandemic Ends (Washington Post) Millions of jobs that have been shortchanged or wiped out entirely by the coronavirus pandemic are unlikely to come back, economists warn, setting up a massive need for career changes and retraining in the United States.

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What is up with Lindsey Graham?

By George Smith

There was a time when he loomed large over the main pack of GOP presidential contenders. He was a political comet, soundin like he was up-to-the-task competent, a man committed to a better America. Then, after being eviscerated by Trump’s broadsword tongue in the primaries, he embraced the liar-in-chief like a scared kindergartner holding onto his mommy at the school door.

Now, after Trump effectively divided the Republican Party into Trumpuppets and anti-Tremors,  Graham is doing his best asshat-duty routine to his fuhrer. There is no apparent reason for his pitiful mouthing.

I believe he is only concerned with … what? Not re-election (doesn’t run again til 2026), not history (his historical fate already set)…so what?

A marital indiscretion Donald is holding over his head? Financial impropriety? Photos of him and a labradoodle?

It’s head-scratching, for sure.

Come back to the light, Lindsey. If not all the way, then, at least, step out of the suffocating, Republican party-killing shadow cast by Trump..

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/14/2021

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/14/2021

HELLO: If you’re busy or in a good mood, don’t read the second article today, or, maybe, ever. Happy Valentine Day. 

The COVID-19 Testing Toolkit

(J. Harris: This is worth downloading to use as a  reference. NEJM sent is out for physicians, but it’s nice and basic. 

HOW COVID MAKES YOU SICK (This material will not be included on the final exam–it’ FYI)

J.Harris: Hobart Burton sent me this article and explanation. The article itself is exceedingly complicated. Here’s how Hobart explains it:

“This article, from Oak Ridge Labs…may be one explanation of why your buddies described intubating a C19 patient was like trying to intubate a brick. The virus instigated dysregulating of the Renin-angiotensin system (RAS), as in down regulating the ACE receptors and up regulating the ACE2 receptors, which created a bradykinin storm in the lungs which caused them to fill up with a substance called hyaluronic acid, creating a hydrogel.  This stuff can absorb 1000 times its weight in water and cause a jello-like substance in the lungs, preventing oxygen intake and preventing CO2 outflow. Nasty. Of course, this also explains many other symptoms of the virus.”  Thank you, Hobart.

J. Harris: The portion of the article that follows describes the clinical aspects of the Covid cases. Most cases are without symptoms and the infected person does not even know he’s sick. This bit of the article is a description of what might happen to some patients, and some or all of the manifestations of this horrible disease: 

Clinical aspects of COVID-19

“According to the CDC, the majority of SARS-CoV-2 infections are asymptomatic or mild. Those that proceed to more severe forms present with fever, a non-productive cough that may result in hemoptysis and shortness of breath. Other common symptoms are myalgia, fatigue, sore throat, nausea, vomiting, diarrhea, conjunctivitis, anorexia, and headache (cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html). Reports from blood studies include leukopenia, eosinopenia, neutrophilia, elevated liver enzymes, C-reactive protein, and ferritin (Fan et al., 2020; Huang et al., 2020; Goyal et al., 2020). Furthermore, autopsies have reported extensive hyaline membrane formation in the lungs of COVID-19 patients …. Specifically, histological analysis of the lungs of a deceased COVID-19 patient showed organizing hyaline membranes in the early stages of alveolar lesions and prominent hyaline membranes in the exudative phase of diffuse alveolar damage… In a seperate post mortem study of lung tissue from COVID-19 patients, microscopic examination found ‘numerous hyaline membranes without evidence of interstitial organization’ … Furthermore, in another autopsy study of a COVID-19 patient, histological analysis found extensive hyaline membranes, which the authors interpreted as indicative of ARDS …. Finally, a meta-analysis showed that there was a statistically significant 4.6 fold difference [increase] in lung weight of COVID-19 patients versus controls, which they conclude is consistent with the HA-hydrogel formation known to occur in ARDS….

Although much focus has been on the lung due to the need for ventilator support of end-stage disease, COVID-19 also affects the intestine, liver, kidney, heart, brain, and eyes ...Nearly one-fifth of hospitalized patients experience cardiac injury… many of whom have had no history of cardiovascular problems prior to infection. Responses include acute myocardial injury, myocarditis, and arrhythmias …. that may be due to viral infection directly, which is consistent with high expression of the SARS-CoV-2 receptor ACE2 in cardiac tissue… An important extension of the RAS[Renin/Antiotensin System] in controlling cardiac contraction and blood pressure is the potent inotrope apelin (APLN), which acts as an NO-dependent vasodilator when its receptor (APLNR) heterodimerizes with BDKRB1 (Bai et al., 2014). APLN (98 fold), APLNR (3190 fold) and BDKRB1 (2945 fold) are all upregulated in COVID-19 BAL. As with BK and ANG derived peptides, APLN is inactivated by Neprilysin (MME), which is significantly downregulated in the BAL samples from COVID-19 individuals (−16 fold). Therefore, increased APLN-signaling can be added to the imbalanced RAS. (I don’t know what any of this italicized portion means.)

In addition to cardiac dysfunction, neurological involvement in COVID-19 was revealed after an MRI assessment of COVID-19-positive patients with encephalopathy symptoms in France identified enhancement in leptomeningeal spaces and bilateral frontotemporal hypoperfusion … which are consistent with increased vascular permeabilization in the brain. Furthermore, earlier reports from China indicate [a lot of] of dizziness, headache, as well as taste and smell impairment …The most recent reports from the United States and China indicate that 30–50% of COVID-19 patients experience adverse gastrointestinal symptoms …. Direct infection by the virus and damage to the kidney was also observed, specifically in the proximal tubules … These latter two findings are not surprising given the higher expression of ACE2 in these tissues compared to tissues overall …, which would facilitate infection by the virus. Finally, COVID-19 patients also frequently display skin rashes, including ‘covid-toe’ that appear to be related to dysfunction of the underlying vasculature.

This diagram explains it all. What a simple solution. It makes one wish to be a Virologist?

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CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/13/2021

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS – 02/13/2021

SARS-CoV-2 variants and ending the COVID-19 pandemic

(J. Harris: This is a short, readable Lancet article that spells out the 4 things that we need to do regarding Covid now and in the future. It also helps that the CDC, NIH, and WHO are being reorganised, better led, and focused. These doctors and their associated University programs are the best Virologists in the world.)

COVID MUTATIONS AND THEIR SIGNIFICANCE 101

Blood thinners as a early COVID-19 treatment could improve mortality rates, study says

The 30-day mortality rate among those who received anticoagulants early was 14 percent, compared to 19 percent among patients who did not.(J. Harris: A VA study.)

Amazon hires founders of COVID-19 testing startup

Amazon has hired several employees of Caspr Biotech, a COVID-19 testing startup, in an effort to curb the spread of COVID-19 among Amazon workers …

Caspr Biotech’s cofounders, CEO Franco Goytia and Chief Strategy Officer Carla Gimenez, were among the employees hired by Amazon. They joined the company in December and are working on a project codenamed Artemis…Amazon said last year it had begun building a lab to test workers for COVID-19. In February, the company said it was testing about 700 workers an hour, according to Bloomberg. 

Vaccines Alone Are Not Enough to Beat COVID

Colchicine reduces the risk of COVID-19-related complications

(J. Harris: Colchicine is an anti-inflammatory drug that is most often used for the treatment of acute gout. [If a red hot swollen joint doesn’t respond to Colchicine, then the arthritis isn’t caused by Gout, or by Pseudogout which is rarer]. Colchicine is not the same as Quinine or Chloroquine, both of which are anti-malaria drugs, neither of which help in Covid treatment. They are all old, plant source medications. 

 Colchicine used to cost $0.09/tablet. However, drug companies and the FDA had deemed it to be an “Orphan Drug” and it now sells for $4.95 per tab. 

When I say something good about Federal Agencies concerned with medicine like the CDC and the NIH, I do not include the FDA, which needs to be completely reorganized and managed, in my opinion. If you have questions, read “Pharma” which is a book that taught me just how little I know about the development, manufacture, and marketing of medicines. It also totally surprised me about the extent of the almost total infestation of the pharmacological businesses with greed, larceny, and inhumanity. Also, “Pharma” taught me that corporate lawyers can structure and stack and commingle corporate entities in devious ways that allow them to commit crimes — and to cover up almost anything. This book explains the narcotic crisis that we are still involved with, how it happened, and who caused it.)

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