April 16, 2020
On the bottom right of the page that comes up, select “News and Updates” which gives you’re the current C-19 count for counties to the west of Harrison County.
FROM JOHNS HOPKINS 15 APRIL:
TEMPORAL DYNAMICS OF VIRAL SHEDDING A Brief Communication article published in Nature presents analysis on temporal trends in viral shedding in COVID-19 patients. The study included data from 94 laboratory-confirmed COVID-19 patients in Guangzhou, China—including 414 total throat swabs taken as long as 32 days after symptom onset—to analyze trends in SARS-CoV-2 viral load.The study also included information on 77 identified transmission events, from both inside and outside China, to analyze SARS-CoV-2 transmission dynamics. The researchers observed high viral load in COVID-19 patients immediately after symptoms presented, which tapered off over a period of approximately 21 days. The researchers concluded that the viral load could potentially peak around the time symptoms present, or possibly slightly earlier. Based on the viral load data and case data from the 77 transmission events, the researchers estimated that 44% of the transmissions occurred during the index case’s pre-symptomatic period and that COVID-19 patients become infectious 2.3 days before symptom onset, with a peak in infectiousness around 0.7 days before symptom onset. The study does not evaluate transmissibility of individuals with asymptomatic infection, and the viral load data may not directly correlate to an individual’s degree of infectiousness. Additionally, the article notes that clinical treatment could affect viral load in COVID-19 patients.
COVID-19 IMPACT ON KIDNEY FUNCTION There is growing evidence that COVID-19 can have serious effects on organs far beyond the lungs. Respiratory distress and failure is perhaps the most recognized clinical presentation in severe COVID-19 patients, but patients are also experiencing damage to the heart, kidneys, central nervous system, and other parts of the body. In particular, kidney failure among COVID-19 patients resulting in increased demand for dialysis and continuous renal replacement therapy. This could be due to a variety of factors, including the treatments used to care for COVID-19 patients or a “cytokine storm” (i.e., overwhelming immune response that can also damage organs and tissues), but there is also preliminary evidence that the damage could be caused by the disease itself. Additional data and research are needed to fully characterize the clinical progression and manifestation of COVID-19, but it appears that the SARS-CoV-2 virus can infect a variety of cells and result in a broad scope of symptoms and damage.
This is a long, detailed Journal of the American Medical Ass. (JAMA) article of more interest to medical people than civilians, but it looks like a very thorough review which, unfortunately shows no pharmacological help yet. The entire article is available:
“Conclusions and Relevance: The COVID-19 pandemic represents the greatest global public health crisis of this generation and, potentially, since the pandemic influenza outbreak of 1918. The speed and volume of clinical trials launched to investigate potential therapies for COVID-19 highlight both the need and capability to produce high-quality evidence even in the middle of a pandemic. No therapies have been shown effective to date.”
A Scientific American article about immunity. Readable.
“At this point it’s inconclusive, although the weight of evidence seems to indicate natural, but we do not know for sure…”
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