CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –1/15/2022

Today, the numbers from the state are not functional. So,  I have used Harrison County numbers from the NYT. What is apparent is that things are WORSE in East Texas.  The Gregg and Smith County numbers are released every three or four days. 

TODAY’S MNM:

COVID IN MARSHALL

FROM BECKER

83% of ICU beds in use nationwide: How each state stacks up

17% of US hospitals critically understaffed, 23% anticipate shortages: Numbers by state

FROM HOPKINS:

1. WHO Recommends Two New Drugs to Treat Patients with COVID-19 (WHO) The drug baricitinib (a type of drug known as a Janus kinase (JAK) inhibitor, also used to treat rheumatoid arthritis) is strongly recommended for patients with severe or critical covid-19 in combination with corticosteroids, says a WHO Guideline Development Group of international experts in The BMJ today. Their strong recommendation is based on moderate certainty evidence that it improves survival and reduces the need for ventilation, with no observed increase in adverse effects.

2. COVID-19 Therapeutics for Nonhospitalized Patients (JAMA) Substantial progress has been made in therapeutics for nonhospitalized patients with COVID-19, but supply of and access to treatment remain limited. This Viewpoint summarizes currently available therapeutics for nonhospitalized patients in the setting of the Omicron variant including principles for equitable allocation. Patients with mild or moderate COVID-19 are those who have respiratory and systemic symptoms but not hypoxia, tachypnea, or other complications that necessitate hospitalization.1 During this early phase of illness, viral replication is occurring and antiviral therapies are used to prevent disease progression, hospitalization, and death.

3/ Even Poorly Matched Flu Vaccines Protect Children from Serious Illness, Study Shows (Healio) A new study reinforced that influenza vaccination protects children from serious illness even when vaccines are a poor match for circulating viruses. The study’s authors found that vaccination during the 2019-2020 season was 63% effective overall against critical influenza among children. Vaccination reduced the risk for severe influenza among children by 78% against influenza A viruses that matched the vaccine viruses, by 47% against mismatched influenza A viruses, and by 75% against mismatched influenza B-Victoria viruses, they reported.

The study comprised 291 patients in 17 U.S. hospitals — 159 children who were critically ill with influenza and 132 controls.

Some experts call for a switch from nasal swabs to saliva-based tests, to better detect Omicron (some of which are manufactured in Marshall.)

NYT ON BURNOUT CRISIS

AND LAST BUT NOT LEASED:

I don’t mean to interrupt people. I just randomly remember things and get really excited.

Prison is just one word to you, but for some people, it’s a whole sentence.

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –12/16/2021

Expecting a Surge….FROM NYT THIS AM. VERY CURRENT.

Booster doses of the Moderna and Pfizer vaccines are likely to offer substantial protection from Omicron, Fauci says. Video

FROM HOPKINS:.THREE GOOD NEWS EXCERPTS:

1. T Cells Might Be Our Bodies’ Best Shot Against Omicron (The Atlantic) Killer T cells, as their name might imply, are not known for their mercy. When these immunological assassins happen upon a cell that’s been hijacked by a virus, their first instinct is to butcher. The killer T punches holes in the compromised cell and pumps in toxins to destroy it from the inside out. The cell shrinks and collapses; its perforated surface erupts in bubbles and boils, which slough away until little is left but fragmentary mush. The cell dies spectacularly, horrifically—but so, too, do the virus particles inside, and the killer T moves on, eager to murder again.

2.Trial Begins of Needle-free Covid Vaccine Targeting New Variants (BBC) A trial has begun of a new needle-free Covid-19 vaccine to protect against future variants of the virus. The vaccine, administered through a jet of air, has been developed by Prof Jonathan Heeney of Cambridge University and chief executive of DIOSynVax. Participants, aged between 18 and 50 years old, will take part at the NIHR Southampton Clinical Research Facility. Prof Heeney said: “As new variants emerge and immunity begins to wane we need newer technologies.”

3. Pfizer Study Confirms 89 Percent Reduction In Hospitalizations And Death For Covid-19 Oral Antiviral (Homeland Preparedness News) Results came in this week from a Phase 2/3 trial of Pfizer Inc.’s COVID-19 oral antiviral treatment, and the data showed a drug capable of cutting risks of hospitalization or death by 89 percent among high-risk adults, when given within a few days of their first symptoms. The final data from the EPIC-HR study, which studied 2,246 participants, confirmed prior efficacy of the Paxlovid treatment, noting that risk reduction to hold when given within three days of symptom onset, followed by a slight reduction to 88 percent when given within five days. In total, five hospitalizations emerged among those treated with Paxlovid pills over the course of 28 days, and no one died. Comparatively, nine of those given placebo in the study died, while 44 were hospitalized.

Princeton, Cornell, Others Urge Students to Head Home Because of Covid-19 Outbreaks

COVID-19: Challenging Clinical QuestionsJ. Harris: Short readable discussion followed by an infectious disease forum, one of 7 which are available to watch:

”…SARS-CoV-2 is a stubborn virus, an alphabet of variants has emerged, testing remains suboptimal, and pandemic fatigue and reliance on misinformation have resulted in too many people choosing not to adhere to recommendations for vaccination and other public health measures. The body of knowledge about SARS-CoV-2 that researchers have amassed since early 2020 is remarkable. Yet, as we learn more, new questions emerge. This is particularly the case in light of the recent recognition of the Omicron variant in late November 2021 and the emergence of promising antiviral therapies….They emphasized the importance of widespread vaccination both to reduce the adverse clinical impact of Omicron and other variants and to prevent the emergence of new variants….There was a robust discussion of the degree to which infection with SARS-CoV-2 protects against subsequent infection. Panelists agreed that infection surely boosted antibody levels, offering some immunity, but the protection was temporary. Vaccination after acute infection clearly augments immunity….Clinicians have many questions about why measuring antibody levels to assess the degree of people’s level of immunity has not become recommended clinical practice. All 3 panelists dissuaded clinicians from measuring antibodies outside of research settings. Commercially available antibody assays are widely variable and questionable in their accuracy…Outpatient therapies, monoclonal antibodies, and oral antivirals are important components of the clinical armamentarium necessary to move us from pandemic to endemic disease…They all agreed that timely and easily accessible COVID-19 testing at sites that are able to administer treatment to people who test positive was necessary to realize the benefit of existing and emerging therapeutics...Panelists emphasized the critical need to expand testing. Even if imperfect, rapid home tests can guide safe behavior as people resume activities, such as travel and gathering with others…Other topics addressed included vaccine side effects, persisting symptoms following acute COVID-19, use of ineffective and even harmful therapies, and emerging data that persons with immunocompromise may have difficulty clearing the virus after acute infection and remain at risk for transmitting infection outside of normal quarantine time frames..”

Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials. Harris: This Chinese vaccine is inactivated, cheap, easy to store and has been used all over the world. I works better when the third does is given after 8 months rather than 2.”...A third dose of CoronaVac in adults administered 8 months after a second dose effectively recalled specific immune responses to SARS-CoV-2, which had declined substantially 6 months after two doses of CoronaVac, resulting in a remarkable increase in the concentration of antibodies and indicating that a two-dose schedule generates good immune memory, and a primary third dose given 2 months after the second dose induced slightly higher antibody titres than the primary two doses…

AND LAST AND THE VERY LEAST:

ODELL BECKHAM JR. IS ALMOST FROM MARSHALL:

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

 Opinion: Definition of Patriot

 Opinion: Definition of Patriot

By George Smith  — December 9, 2021

Let’s talk straight.

Definition of patriot

”one who loves and supports his or her country”

If you believe the results of the 2020 elections are false and you believe the election was  stolen from Donald Trump…you are not a patriot.

If you would vote for Trump in 2024… you are not a patriot.

If you refuse to acknowledge that the Jan. 6, 2021 attack of the Capitol was NOT an insurrection attempt and a domestic terrorist attack…you are not a patriot.

If you are a supporter of Majorie Taylor Greene, Lauren Boebert or Paul Gosar, or Sens. Mitch McConnell, Tom Cotton or Ted Cruz, you are not a patriot, but a wrong-headed follower of suppression politics.

All of those legislators are only interested in two things…and the fate of the country is not one of them. They all have two things in common: Power…getting it and holding onto it, and money, getting it and getting more of it.

To those folks, the fate of the country and its foundation of democracy are secondary to personal gratification in gaining and holding onto power.

If you value democracy, you cannot support those that want to dilute freedoms that define America, including equality and justice for all and preserving a democratic form of government.

It’s time for real patriots to stand up to the false idolatry worshippers who advocate the suppression of entire classes of voters in order to increase their support base.m, and, thus, individual power.

Let your voices be heard. It’s the right thing to do…the American thing to do.

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

A day in the Life of Sue Republican

A day in the Life of Sue Republican

Sue gets up at 6 a.m. and fills her coffeepot with water to prepare her morning coffee. The water is clean and good because some tree-hugging liberal fought for minimum water-quality standards.

With her first swallow of coffee, she takes her daily medication. Her medications are safe to take because some stupid commie liberal fought to insure their safety and  that they work as advertised.

All but $10 of her medications are paid for by her employer’s medical plan because some liberal union workers fought their employers for paid medical insurance – now  Sue gets it too.

She prepares her morning breakfast, bacon and eggs. Sue’s bacon is safe to eat because some girly-man liberal fought for laws to regulate the meat packing industry.

In the shower, Sue reaches for her shampoo. Her bottle is properly labeled with each ingredient and its amount in the total contents because some crybaby liberal fought  for her right to know what she was putting on her body and how much it contained.

Sue dresses, walks outside and takes a deep breath. The air she breathes is clean because some environmentalist wacko liberal fought for laws to stop industries from  polluting our air.

She walks to the subway station for her government-subsidized ride to work. It saves her considerable money in parking and transportation fees because some fancy-pants  liberal fought for affordable public transportation, which gives everyone the opportunity to be a contributor.

Sue begins her work day. She has a good job with excellent pay, medical benefits, retirement, paid holidays and vacation because some lazy liberal union members fought  and died for these working standards. Sue’s employer pays these standards because Sue’s employer doesn’t want his employees to call the union.

If Sue is hurt on the job or becomes unemployed, she’ll get a worker compensation or unemployment check because some stupid liberal didn’t think she should lose her home  because of her temporary misfortune.

It’s noon and Sue needs to make a bank deposit so she can pay some bills. Sue’s deposit is federally insured by the FSLIC because some godless liberal wanted to protect  Sue’s money from unscrupulous bankers who ruined the banking system before the Great Depression.

Sue has to pay her Fannie Mae-underwritten mortgage and her below-market federal student loan because some elitist liberal decided that Sue and the government would be  better off if she was educated and earned more money over her lifetime.

Sue is home from work. She plans to visit her father this evening at his farm home in the country. She gets in her car for the drive. Her car is among the safest in the  world because some America-hating liberal fought for car safety standards.

She arrives at her childhood home. Her generation was the third to live in the house financed by Farmers’ Home Administration because bankers didn’t want to make rural  loans. The house didn’t have electricity until some big-government liberal stuck his nose where it didn’t belong and demanded rural electrification.

She is happy to see her father, who is now retired. Her father lives on Social Security and a union pension because some wine-drinking, cheese-eating liberal made sure  he could take care of himself so Sue wouldn’t have to.

Sue gets back in her car for the ride home, and turns on a radio talk show. The radio host keeps saying that liberals are bad and conservatives are good. He doesn’t mention  that Republicans have fought against every protection and benefit Sue enjoys throughout her day. Sue agrees: “We don’t need those big-government liberals ruining our lives! After all, I’m self-made and believe everyone should take care of themselves, just  like I have”.

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

Opinion: Butts, bed sheets and horizontal gravity

 Opinion: Butts, bed sheets and horizontal gravity

By George Smith  — December 1, 2021

Ohhhhh, sometimes the mind climbs out of the proverbial “box” on its own.

Butts, bed sheets and horizontal gravity

I’ve never claimed that a certain percentage of my thoughts are what one might call “normal.” It is (pick one) A) a blessing, or a curse to have thoughts that sometimes fall outside the realm of those shared by a vast majority of people.

Since I have them on occasion, I go with A.

An example: Have you ever been sitting up in bed, leaned against the headboard, pillows at your back, thumbing the heck out of a good novel and all of a sudden … you realize you have slid down in the bed without realizing it? Instead of being in a sitting position, you find yourself practically supine! How did that happen?

I surmise it’s a little known and totally misunderstood element of physics – horizontal gravity. As you might surmise, there’s got to be more to it than just the fact that scientists and philosophers have overlooked this phenomenon for the past several thousand years, ever since the invention of sheets with thread count over six. Not 600, but six.

I have come to the belief that there is a direct correlation between the thread count of sheets, the square inch-ary of butt surface and the theory of horizontal gravity. Check that: It is my contention that horizontal gravity is not a theory, but an existing condition that has not been properly studied.

That’s about to change.

I am writing a federal grant to study the phenomenon and, with the bringing-home-the-bacon money available from my elected officials, I expect to get started as soon as my grant can be approved, which should be as soon as this latest, silly Middle East conflict question can be resolved. Knowing members of congress like I do, I know it’s easy to stick this type of expenditure as a “tail-er” on a bigger bill about nuclear proliferation or some such.

I have already done sufficient research to warrant the grant that I value at about $49,750. (I am convinced if I keep it under $50,000, it is such a fiscal pimple as to be invisible in any General Account Office audit.)

You want proof of my initial reasoning and research? How’s this: Sheets vary widely in thread count, as well as material from which they are constructed; 300-, 600-, 800-thread count sheets are commonplace. It is easy to buy higher thread count sheets of up to 1,800 threads per square inch (900 vertical and 900 horizontal). A higher thread count than that and you have Sarah Wrap.

A portion of the study will have to do with the surface area of butts on bed sheets. I am firmly convinced that the total surface area of a butt will slide horizontally in direct proportion to thread count; the bigger the butt surface, the faster the horizontal movement.

Of course, the study will have to include the movement of bare buttocks vs. clothed; the type of covering material or lack thereof and its affect on rate of horizontal movement will have its own section in the final report.

Those of you who may scoff at my research grant proposal do not know the depth of federal grant follies. Do you know whether or not it is economically feasible to create bite-sized bales of hay for cows? It is not economically feasible according to a 1980s federal grant to the University of Michigan.

What is the composition of 17th Century violin varnish? We know this important fact due to a federal grant.

And federal funds were used to compile the history of comic books.

Surely, a study to research the theory of horizontal gravity is just as important.


iExposed Us

P.O. Box 721

Scottsville Texas


CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –11/26/2021

HELLO,

FIND VACCINE PROVIDERS: http://www.vaccines.gov75670      (or your zip code)

NEW AFRICAN VARIANT

”…scientists are at work to study the new B.1.1.529 variant,…..In December last year, South Africa was the first nation to report the appearance of the Beta variant, which has now spread to nearly 70 countries. Scientists have been concerned that some clinical trials have shown that vaccines offer less protection against the Beta variant. Since then, the more virulent and aggressive Delta variant has spread all over the world…..In the past two days, scientists detected the variant after observing an increase in infections in South Africa’s economic hub surrounding Johannesburg. So far only a few dozen cases have been identified in South Africa, Hong Kong, Israel and Botswana…..This variant did surprise us — it has a big jump in evolution, many more mutations than we expected….

What scientists know about the new variant, B.1.1.529.

”…..Scientists are still unclear on how effective vaccines will be against the new variant flagged by a team in South Africa, which displays mutations that might resist neutralization. Only several dozen cases have been fully identified so far in South Africa, Botswana, Hong Kong and Israel……B.1.1.529, has a “very unusual constellation of mutations,” with more than 30 in the spike protein alone,….. the protein that helps to create an entry point for the coronavirus to infect human cells — the new variant has 10 mutations. In comparison, the Beta variant has three and the Delta variant two…..The new variant has largely been detected among young people, the cohort that also has the lowest vaccination rate in South Africa…..While cases of the variant are mainly concentrated in the country’s economic hub, particularly in the country’s administrative capital, Pretoria, it is “only a matter of time” before the virus spreads across the country as schools close and families prepare to travel for the holiday season,….

THE COVID FABLE

More Covid Mysteries (July 2021)

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –11/23/2021

FIND VACCINE PROVIDERS: http://www.vaccines.gov75670      (or your zip code) 

I’M GOING FISHING. RETURN PROBABLE.  GET YOUR 3RD JAB

A Texas court affirms a ruling against the governor’s ban on mask mandates.

”…Officials in Dallas and elsewhere in Texas have defied the governor by requiring people to wear masks in schools and other indoor public settings…The chief elected official in Dallas County celebrated a victory on Tuesday in his legal dispute over the governor’s ban on mask mandates, after a state appeals court upheld an earlier injunction against the ban.

FROM BECKER:

1. The cost of nurse turnover by the numbers

2. Fauci shares holiday guidance as COVID-19 cases continue to climb

HOPKINS CITED:

1. Impact of Hospital Strain on Excess Deaths During the COVID-19 Pandemic — United;States, July 2020–July 2021

”…Surges in COVID-19 cases have stressed hospital systems, negatively affected health care and public health infrastructures, and degraded national critical functions (1,2). Resource limitations, such as available hospital space, staffing, and supplies led some facilities to adopt crisis standards of care, the most extreme operating condition for hospitals, in which the focus of medical decision-making shifted from achieving the best outcomes for individual patients to addressing the immediate care needs of larger groups of patients (3). When hospitals deviated from conventional standards of care, many preventive and elective procedures were suspended, leading to the progression of serious conditions among some persons who would have benefitted from earlier diagnosis and intervention…”

2. Susceptibility of Livestock to SARS-CoV-2 Infection (Emerging Microbes and Infections) We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2. None of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral RNA was detected in several animals. Further, neutralizing antibody titres were low or non-existent one month following infection. These results suggest that domestic livestock are unlikely to contribute to SARS-CoV-2 epidemiology.

(J. Harris: This doesn’t include pets like cats and dogs and other little furry creatures.)

3. Pfizer’s Covid-19 Vaccine Was 100% Effective in Kids in Longer-term Study (STAT News) Pfizer and BioNTech announced Monday that their Covid-19 vaccine was 100% efficacious in preventing infections in 12- to 15-year-olds, measured from seven days to four months after administration of the second dose of the vaccine. The companies said the new data — a longer-term analysis of a Phase 3 trial conducted in 2,228 participants — will form the basis of an application to the Food and Drug Administration for an extension of their Covid-19 vaccine license to cover youths in the age group. The longer-term analysis of the Phase 3 trial data showed no serious safety concerns over a follow-up period of at least six months after the second dose of the vaccine.

FROM JAMA MONDAY:

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older NONE

In this nationwide study involving persons aged 75 years or older in France, no increase in the incidence of acute myocardial infarction, stroke, and pulmonary embolism was detected 14 days following each BNT162b2 mRNA vaccine dose.

[PFIZER]

Israeli and US studies reported that persons receiving the BNT162b2 vaccine were not at increased risk of myocardial infarction, pulmonary embolism, or cerebrovascular events in the 42 days3 and 21 days4 following vaccination. Based on a self-controlled case-series design that compensates for the lack of randomization by eliminating the effect of time-invariant confounding factors, this study provides further evidence regarding the risk of serious cardiovascular adverse events in older people. Limitations of the study include the possibility of residual time-dependent confounding….Further investigations are needed to measure these risks in younger populations and for other types of vaccines against SARS-CoV-2.

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –11/20/2021

HELLO, 

Covid is taking a break in our area. Have a nice weekend but remain cautious.

NOTE FROM A VERY EXPERIENCED PRIVATE INTERNIST REGARDING NEW ANTIVIRAL (COVID) ORAL DRUGS USE:

‘’Tests for Covid are likely most sensitive on day 4 of symptoms for a pill that needs to be given by day 3.

‘’Not enough people have immediate access to rapid PCR tests for Covid to see if they are infected, so these pills cannot change a Covid epidemic. Quick antigen tests are great when positive but often falsely negative, especially in that first three-day window.

“THEREFORE: if the pill is going to change the game it will need to be “allowed” to be given the same way that flu medicine (Tamiflu) is given, which is if Dr. Harris or Dr. X  think you have the infection right now, test or no test,  they will prescribe the antiviral medication… (Office flu tests perform with very similar low sensitivity/high specificity that Covid antigen, does so use a few early in the season then just make clinical diagnosis because Tamiflu also must be given early to help.)

“TAKE HOME: The antiviral oral drugs must be affordable and, more importantly, if doctors must be freed up to prescribe the drugs early, based on clinical grounds,  without a test to prove it is definitely Covid.  If doctors are not allowed by the government to treat early without waiting for positive tests, there will not be enough of the medicine prescribed to change the epidemic — even though it helps those patients fortunate enough to have been treated with it early, positive test or not.

‘’(The Tamiflu analogy is fine but this pill works different and better than Tamiflu and the bad part of the analogy is it lulls us into thinking the two diseases are comparable and they are not–one of ’em can kill you, the other, grievously hurts your feelings but usually not forever.”

With COVID cases spiking, no end in sight ( My doctor friend also sent this article)

”…We want control,” Fauci said. “And I think the confusion is, at what level of control are you going to accept it in its endemicity?”

A virus becomes endemic when it is no longer spreading at pandemic levels but is also impervious to actual eradication. Downgrading the coronavirus to an endemic pathogen would in effect concede that we will live with it for the foreseeable future, but without the disruptions caused by pandemic spread….The goal isn’t quite as modest as it seems, since only one virus — smallpox — has ever been eradicated. If the coronavirus became endemic, it would be relegated to a seasonal problem, similar to the influenza that invariably shows up with the cold weather…”

Could oral antiviral pills be a game-changer for COVID-19? An infectious disease physician explains why these options are badly needed

 ( J. Harris: News Summary today from Yahoo that discusses the need for almost immediate use of the oral drugs to get any benefit from them:)

Molnupiravir reduced the risk of death or hospitalization by about 50% in non-hospitalized adult patients with mild to moderate COVID-19 when treated within five days of symptom onset. Paxlovid reduced this risk by about 89% for patients treated within three days of symptoms and 85% for patients treated within five days. Importantly, no patients who took either drug died in the studies. Because the drugs were not studied head to head, it’s difficult to say whether one will be better than the other in the real world. In early November, Britain became the first country to approve molnupiravir for use…Molnupiravir did not help hospitalized patients [who are generally already sick for several days] recover faster from COVID-19. It is likely that Paxlovid would also not be useful at the point of hospitalization. Most patients who are in the hospital with COVID-19 are sick because of unregulated inflammation and not because the virus is still replicating in their bodies….Researchers are also working on repurposing existing drugs to treat COVID. Inhaled steroids like budesonide and an antidepressant called fluvoxamine are particularly promising…

While it’s exciting to see new treatments for COVID-19, prevention is still the best strategy. The COVID-19 vaccines continue to be the most effective tool for helping to end the pandemic.

FROM HOPKINS:

1. F.D.A. Authorizes Coronavirus Booster Shots for All Adults (New York Times) The Food and Drug Administration on Friday authorized booster shots of both the Pfizer-BioNTech and Moderna vaccines for everyone 18 and older, opening up eligibility to tens of millions more fully vaccinated adults. The move simplifies eligibility, fulfills a pledge by President Biden to offer the shots to every American adult and formally allows a practice already in place in at least 10 states. Fearful that waning protection and the onset of winter will set off a wave of breakthrough infections, a growing number of governors had already offered boosters to everyone 18 and older ahead of the holidays.

Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age

”...This study describes immunization against SARS-CoV-2 infection with an mRNA vaccine in children younger than 12 years of age and documents the safety, immunogenicity, and efficacy of a Covid-19 vaccine in this population; trials of other vaccines are under way.Direct benefits of preventing SARS-CoV-2 infection in children include protection against severe disease, hospitalizations, and severe or long-term complications, such as MIS-C. Indirect benefits include the likelihood of reduced transmission in the home and in school settings, including transmission affecting vulnerable persons, and safer in-person learning.26-29 Without effective Covid-19 vaccines for this age group, children could potentially become ongoing reservoirs of infection and sources of newly emerging variants.26,30 Covid-19–associated school closures and quarantines also have social and economic costs for families and caregivers.16-19 Widespread vaccination across age groups is therefore essential in ongoing efforts to curtail the pandemic….A Covid-19 vaccination regimen consisting of two 10-μg doses of BNT162b2 administered 21 days apart was found to be safe, immunogenic, and efficacious in children 5 to 11 years of age…. The robust virus-neutralizing response observed in 5-to-11-year-olds was similar to that seen in 16-to-25-year-olds from the pivotal trial, which demonstrated 95% vaccine efficacy among persons at least 16 years of age from 7 days to approximately 2 months after the second dose.3 Immunobridging…”

AND LAST BUT NOT LEASED:

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

72688

CORONAVIRUS INFO PROVIDED BY DR. JIM HARRIS –11/06/2021

Pediatric COVID-19 Vaccines What Parents, Practitioners, and Policy Makers Need to Know. (Click)

(J. Harris: Very readable and reassuring for parents and grandparents.)

NEW FROM HOPKINS TODAY:

Why Is Delta So Infectious? New Lab Tool Spotlights Little Noticed Mutation That Speeds Viral Spread (Science) As the world has learned to its cost, the Delta variant of the pandemic coronavirus is more than twice as infectious as previous strains. Just what drives Delta’s ability to spread so rapidly hasn’t been clear, however. Now, a new lab strategy that makes it possible to quickly and safely study the effects of mutations in SARS-CoV-2 variants has delivered one answer: a little-noticed mutation in Delta that allows the virus to stuff more of its genetic code into host cells, thus boosting the chances that each infected cell will spread the virus to another cell. That discovery, published today in Science, is “a big deal,” says Michael Summers, a structural biologist at the University of Maryland, Baltimore County—not just because it helps explain Delta’s ravages. The new system, developed by Nobel Prize winner Jennifer Doudna of the University of California (UC), Berkeley, and her colleagues, is a powerful tool for understanding current SARS-CoV-2 variants and exploring how future variants might affect the pandemic, he says. “The system she has developed allows you to look at any mutation and its influence on key parts of viral replication. … That can now be studied in a much easier way by a lot more scientists.”

JAMA DAY:

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity

Unvaccinated patients accounted for 93.9% (261/278) of cases with disease progression to death or invasive mechanical ventilation.

Unvaccinated patients accounted for 91.0% (91/100) of deaths among patients with COVID-19 in this study. Death occurred in 9 of 142 (6.3%) vaccine breakthrough cases and 91 of 1055 (8.6%) unvaccinated patients with COVID-19. Progression to death after COVID-19 hospitalization was associated with a lower likelihood of vaccination (aOR, 0.41; 95% CI, 0.19-0.88).

(J. Harris: This JAMA article if readable and the vaccine hesitant folks should read it. It is a life or death matter if you get carless and catch Covid.)

EDITORIAL EXPLAINING THE ABOVE ARTICLE AND SOME CONCERNS

”…The current surge in infections with the SARS-CoV-2 Delta variant has made it clear to health care workers and the public alike that fully vaccinated people remain at risk for SARS-CoV-2 infections…Vaccines not only decrease transmission rates, but also decrease disease severity among individuals who do acquire infection. Vaccinated people with breakthrough infections, including infection with the Delta variant, are less likely to develop symptoms, less likely to develop severe symptoms, more likely to recover from their illness quickly, and much less likely to require hospitalization compared with unvaccinated people.8,12 As of August 28, 2021, the age-adjusted rate of hospitalization among US adults aged 18 years or older was 83.6 per 100 000 for unvaccinated persons compared with 4.5 per 100 000 for fully vaccinated persons.13…On balance, the study by Tenforde and colleagues offers equal measures of reassurance and concern. The reassurance is that mRNA vaccines are highly effective against hospitalizations, that this benefit is preserved against the Delta variant, and that when breakthrough infections lead to hospitalization, the clinical course is milder and less likely to require intubation or culminate in death. The concerns are that mRNA vaccines are much less effective in preventing hospitalizations for immunocompromised individuals compared with immunocompetent individuals and that protection against hospitalizations for all people may wane over time, particularly for the mRNA BNT162b2 vaccine. Fortunately, emerging data suggest boosters may mitigate these risks.

Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Adults Aged ≥60 Years (GOOD NEW!)

This study found that a third BNT162b2[PFIZER] dose in adults aged 60 years and older was associated with significantly increased IgG titers after 10 to 19 days, with no major adverse events……A third dose of the SARS-CoV-2 mRNA-1273 vaccine (Moderna) induced seropositivity in 49% of kidney transplant recipients [GROSSLY IMMUNOCOMPRAMISED] who did not respond after 2 vaccine doses,3 although this observation cannot be generalized to older adults. In a study from Israel among 1 137 804 adults aged 60 years and older who had received 2 BNT162b2 doses 5 or more months earlier, a third dose was associated with lower rates of confirmed SARS-CoV-2 infections and severe illness.4 This study adds serologic data to the clinical data on response to a third dose in adults aged 60 years or older.

(J. Harris: This great Moderna response might make “mix and match” worth considering for Pfizers vaccinated folks and definitely for those who too J &J vaccines. I’m watching this issue.)

(J. Harris: So, this group of unimmunized old folks is going to clog up the hospitals again this winter?)

LAST BUT NOT LEASED:

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

Click here to go to the iExposed.us website

—————————————————————–

iExposed Us 

P.O. Box 521

Scottsville Texas

72688

Memorial Day Activities

Ringing of church bells and brief musical commemoration

of a carillon of bells to take place in downtown Marshall 

at the traditional 11 o’clock hour on Veterans Day, November 11

In 1919, President Woodrow Wilson proclaimed November 11 as the first commemoration of Armistice Day in the United States of America. The date of November 11 marked the armistice which was signed in 1918 between the Allies of World War I—which included France, Great Britain, Russia, Italy, Japan, and the United States—and the Central Powers, which included Germany, Austria-Hungary, the Ottoman Empire, and Bulgaria.

The Armistice between the Allies and the Central Powers was signed in Compiegne, France to proclaim the cessation of hostilities on the Western Front which would take place that morning, November 11, 1918. That was how the tradition of the “eleventh hour of the eleventh day of the eleventh month” began.

In 1954, U.S. Representative Edward Rees of Kansas proposed a bill that would change Armistice Day to Veterans Day. That year, Congress passed the bill which President Dwight Eisenhower signed, proclaiming November 11 as Veterans Day.

This year, on Veterans Day, Thursday, November 11, the “eleventh hour of the eleventh day of the eleventh month” will be commemorated in downtown Marshall with the ringing of church bells at 11:00am, in coordination with the 11:00am chimes of the restored 1901 Harrison County Courthouse.

The ringing of the bells will be done by three downtown churches—Trinity Episcopal Church, St. Joseph Catholic Church, and First United Methodist Church. 

Following the ringing of the bells, the newly-installed, beautiful carillon of bells of the First United Methodist Church of Marshall, located one block east of the Courthouse Square, will play patriotic music to pay tribute to the brave service and sacrifice of all veterans, as well as those who currently serve in the military.

Following the playing of the patriotic music, “Taps” will be played to end the brief commemoration. 

Christina Anderson, the volunteer who has headed the coordination of the Marshall-Harrison County Community Veterans Day program for many years, shared: “As our veterans and community members may know, we usually have a program at the traditional 11 o’clock hour on Veterans Day to honor and express appreciate to our local veterans for their brave service and sacrifice to protect our nation.”

This is the service that had originally been held at the Marshall Mall and more recently at Memorial City Hall. Last year, due to COVID-19 restrictions, an outdoor procession of county, city, and community vehicles around the Courthouse Square was held at the 11 o’clock hour.

Ms. Anderson added: “When we received the news that the Marshall Elks Lodge was planning a wonderful Veterans Parade for the Saturday after Veterans Day on November 13, I contacted the veterans and veteran organizations with whom I coordinate each year for the annual program and the consensus was they felt that a full program would not be necessary this year on Veterans Day since the Elks Lodge was sponsoring a Veterans Parade on Saturday, November 13.”  

But, Ms. Anderson went on to explain that, even though there would not be the full Veterans Day program this year, they still wanted to honor our veterans and commemorate the traditional “eleventh hour of the eleventh day of the eleventh month.” 

So, she shared that, to honor and pay tribute to our veterans on Veterans Day, there will be a large sign of appreciation displayed on the lawn west of The Marshall Grand, in addition to the American flags provided by the Rotary Club of Marshall and, at 11:00am, the very brief bell and musical commemoration, described above, would take place.

Ms. Anderson added, “Though brief, this musical commemoration at the 11 o’clock hour on Veterans Day is designed to convey the profound and abiding gratitude that our community wishes to express to all veterans for their courageous service and sacrifice for our nation. There are not enough words to convey the deep appreciation we feel—not just on Veterans Day, but every day—on behalf of all Americans.”

Special thanks to the all our veterans and veteran organizations. Thank you also to the members of Trinity Episcopal Church, St. Joseph Catholic Church and the Knights of Columbus, and First United Methodist Church for collaborating on the ringing of bells with the Harrison County Courthouse.

Also, an additional thank you to Reverend David Luckert, Pastor of the First United Methodist Church (FUMC), for graciously coordinating the playing of patriotic music for the commemoration with the church’s new, beautiful carillon of bells.

Veterans and community members are encouraged to attend or participate in the Veterans Parade, sponsored by the Marshall Elks Lodge #683. The parade will take place on Saturday, November 13 at 10:00am.  

The deadline for entries into the parade is November 8. For more information about the Veterans Parade, please call Melanie Valdez at (903) 407-5251 or Kelly Baker at (903) 472-3306 or Jackie Degner (903) 407-8840.  ##

***********************************

GIVE US YOUR FEEDBACK.  CLICK ON “COMMENT” TO TELL US WHAT YOU THINK or use one of the alternative methods for providing feedback.

Click here to submit feedback.  Let us know what you think.

click here to CLOSE THIS PAGE

—————————————————————–

Click here to go to the iExposed.us youtube channel

—————————————————————–

iExposed Us 

P.O. Box 721

Scottsville Texas

75688