Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

”…Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (Mpro) inhibitor with potent pan–human-coronavirus activity in vitro….Our data show that treatment with nirmatrelvir plus ritonavir early in Covid-19 illness can decrease progression to severe disease and quickly reduce SARS-CoV-2 viral load….Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir resulted in a risk of progression to severe Covid-19 that was 89% lower than the risk with placebo, without evident safety concerns.


1. 10 places where COVID-19 cases are projected to jump the most

2. Arkansas hospital replaces CEO

Magnolia (Ark.) Regional Medical Center has appointed a new leader to replace CEO Rex Jones, who is exiting his role in late April.

The hospital announced in February that Mr. Jones is stepping down to take on a new position with the Arkansas Rural Health Partnership, a nonprofit organization formed in 2008 to improve healthcare delivery in rural Arkansas. His last day at the hospital will be April 24.

The board has selected Brett Kinman to succeed Mr. Jones. Mr. Kinman, who has more than 25 years of healthcare management experience, will step into the position in May.

Mr. Kinman most recently served as administrator of Christus Good Shepherd Medical Center in Marshall, Texas, and Christus St. Michael Hospital in Atlanta, Texas.


1. Los Angeles Covid Test Positivity Rising Rapidly; Only Time Will Tell If Hospitalizations Follow Suit

2. Is herd immunity for Covid-19 still possible?

(J. Harris: Excellent article for herd immunity and new vaccine needs.)


Coronavirus cases strain England’s bid to reduce hospital treatment backlogs, doctors say.

”…So many health professionals and patients have tested positive for the coronavirus in England that the situation has made it hard to address a backlog of more than six million people awaiting hospital treatment for other conditions, health leaders said on Thursday….As the restrictions were lifted, though, the highly transmissible Omicron subvariant known as BA. 2 was spreading through the country, and reports of new cases soared again. Britain’s Office of National Statistics estimated that almost 4.4 million people in England and Wales were infected in a single week in late March, and the percentage of test results that were coming back positive reached record highs….”

South Korea will end virtually all Covid restrictions, except for a mask mandate

”…South Korea plans to phase out virtually all of its coronavirus restrictions, except for a mask mandate, starting next week, ending the curbs on business and social life that it has maintained in some form for two years….“It’s inevitable that we’ll have to keep wearing a mask indoors for a long time, ….South Korea first imposed coronavirus restrictions in March 2020, applying them to churches and some industries where the risk of infection was considered high. A wave of infections driven by the BA.2 Omicron subvariant has been ebbing in recent weeks; on Friday, the health ministry reported an average of 160,191 daily cases over the past seven days, down from 404,998 about a month ago….”


Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis


Understanding of COVID-19 from infection–fatality ratio

J. Harris: (Statistics are not an area of expertise for me. The world wide covid numbers through Nov, 2022 are presented. Since each variant is a little different, I wonder how useful these numbers are? In addition, the infections have already killed off the sickest of the older population. We have several readers who know how to work a slider rule. Maybe we can get some outside opinions. 0

”…Another important concept, the infection–fatality ratio (IFR), has been rarely mentioned. The IFR is crucial for risk perception, policy making for epidemic control, and estimation of COVID-19 burden. The IFR is calculated as COVID-19 deaths divided by the number of people infected with SARS-CoV-2, the denominator of which cannot be directly obtained and could be estimated with data from seroprevalence surveys…..The authors explored the IFR variation from three dimensions including age, geography, and time, which all have important and specific public health implications…. For now, vaccination is the most important intervention to reduce resurgence and transmission of COVID-19 epidemics and lower the number of new fatalities.6,  7 Other promising SARS-CoV-2 antivirals are extending pandemic control to pharmaceutical intervention. With more promising weapons to fight against COVID-19, whether IFR will continue to reduce after the prevaccination era needs to be answered by future studies. As the COVID-19 pandemic continues, society has to be prepared for and adapt to the potential for living with SARS-CoV-2 in the coming years…”


1. “He is simply a shiver looking for a spine to run up. – Paul Keating

2. “He loves nature in spite of what it did to him.” – Forrest Tucker

3. “Why do you sit there looking like an envelope without any address on it?” – Mark Twain


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