There are several interesting articles coming in the next 3 days. I will try to foster relevance.

Tomorrow, I will cut down or discontinue the above flowsheet — forever I hope but doubt.

COVID-19 pediatric vaccines to be available at Tuesday vaccine clinic in Marshall (adults too)

Maybe the schools will sponsor vaccinations on campus?

The Future of SARS-CoV-2 Vaccination — Lessons from Influenza

(J. Harris: Good, readable article that describes our future with Covid which will be similar to that of influenze.  The natural history of influenze illness and vaccines is described and is likely to be the course of Covid disease, prevention, and treatment in the future. )

”….Elimination of an illness by means of herd immunity works best when the agent has low transmissibility, and it requires the absence of pockets of susceptible people…. But we can now see a picture emerging in which use of effective vaccines will continue to be critical over the long term. Increases in asymptomatic infections and mild illnesses in vaccinated people will nonetheless continue to be possible, as variants continue to emerge….The possibility of severe illnesses in a small proportion of vaccinated people does emphasize one of the greatest unmet needs we currently face: continued emphasis on better therapeutics and antiviral agents, which will not be affected by molecular changes in the virus as much as vaccines are…The future timing and composition of booster vaccine doses will need to be determined on the basis of observational studies. We currently have few data on non-mRNA vaccines, particularly protein-based vaccines, which may have characteristics different from those of mRNA vaccines, especially in terms of duration of immunity….


Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

(J. Harris: Pfizer vaccine study results with controls. Has a 2 min. video as well.)

From Becker:

Researchers identify gene tied to increased risk of respiratory failure from COVID-19

”…People with a specific version of a gene known as LTZFL1 may be at increased risk of respiratory failure from COVID-19, according to research published Nov. 4 in Nature.

Researchers from University of Oxford in the U.K. found a higher-risk version of the gene may prevent the cells lining airways and the lungs from responding to the SARS-CoV-2 virus properly, which may double the risk of respiratory failure.

National Retail Sales of Alcohol and Cannabis During the COVID-19 Pandemic in Canada (Readable. Predictable)

Cannabis Use During the COVID-19 Pandemic in Canada: A Repeated Cross-sectional Study

…Risk characteristics associated with higher odds of an increase in cannabis use included residence in the central region (Odds ratio, 95% confidence intervals: 1.93, 1.03-3.62), being 18 to 29 years old (2.61, 1.32-5.17) or 30 to 49 years old (1.85, 1.07-3.19), having less than college or university education (1.86, 1.13-3.06) and being somewhat worried about the pandemic’s impact on personal finances (1.73, 1.00-3.00).

Conclusions: A large proportion of those who used cannabis have increased cannabis use during the pandemic, suggesting a need for interventions to limit increased cannabis use, policy measures to address cannabis-attributable harms, and continued monitoring of cannabis use during and after the pandemic.


There’s More Demand For Boosters Than First Shots Of The Covid Vaccine (NPR) The number of people getting COVID-19 vaccine boosters in the U.S. is now far outpacing the number getting their first shots, according to the Centers for Disease Control and Prevention. That trend represents a big success for White House’s aggressive booster campaign. But it also underscores the administration’s flagging effort to achieve its high priority of vaccinating the remaining unvaccinated Americans. More than 21 million people have already received a booster in the short time they’ve been widely available, according to the CDC website. And more than 786,000 are getting boosters every day now on average. That’s nearly triple the number coming in for their first shots, though the rollout to kids under 12 could potentially change that equation.

2. Sars-Cov-2 Vaccine Protection And Deaths Among Us Veterans During 2021 (Science) We report SARS-CoV-2 vaccine effectiveness against infection (VE-I) and death (VE-D) by vaccine type (n = 780,225) in the Veterans Health Administration, covering 2.7% of the U.S. population. From February to October 2021, VE-I declined from 87.9% to 48.1%, and the decline was greatest for the Janssen vaccine resulting in a VE-I of 13.1%. Although breakthrough infection increased risk of death, vaccination remained protective against death in persons who became infected during the Delta surge. From July to October 2021, VE-D for age 65 years was 73.0% for Janssen, 81.5% for Moderna, and 84.3% for Pfizer-BioNTech; VE-D for age ≥65 years was 52.2% for Janssen, 75.5% for Moderna, and 70.1% for Pfizer-BioNTech. Findings support continued efforts to increase vaccination, booster campaigns, and multiple, additional layers of protection against infection.

3. Colorado Hospitals are Nearly Full as the State Battles a Growing Caseload. (New York Times) Colorado is experiencing its worst coronavirus wave in a year and its overwhelmed hospitals are now allowed to turn away new patients. An executive order, signed on Sunday by Gov. Jared Polis, allowed hospitals to redirect incoming patients. Many medical facilities have reported being over 90 percent capacity, with severe staffing shortages.




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