Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

J. Harris: Good news. No real problems in this small study of the new vaccine in older folks. I plan to take it if and when I can. 


In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports the use of the 100-μg dose in a phase 3 vaccine trial. 

Covid-19 Vaccine: How Do They Work?

J. Harris:  This is a good, simple, understandable, accurate, quick look at vaccines. By the way, Dr. Fauchi said that the vaccine he planned to take was the one that  was available when it was his turn to get one. He had no preference which vaccine to take.

The Coronavirus Is Mutating. What Does That Mean for Us?

By Apoorva Mandavilli

Dec. 20, 2020

J. Harris: If you woke up this morning worrying about mutating viruses, as did I, read this article. It’s reassuring, and, I believe, accurate. As time goes by, we will have to redesign our vaccines to address mutations, but the new vaccines are easier and quicker to reformulate than ever before. Hopefully, we’ll never be caught almost completely unprepared again. CHEER UP; we can handle this virus. Play it safe and take the vaccine when your time comes. 

“…The good news is that the technology used in the Pfizer-BioNTech and Moderna vaccines is much easier to adjust and update than conventional vaccines. The new vaccines also generate a massive immune response, so the coronavirus may need many mutations over years before the vaccines must be tweaked…”.


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