July 16, 2020
NEW COVID CASES FROM AREA:Harrison County: 8Gregg County: 42Smith County: 69 (only one found on routine testing apparently–the rest are newly sick).
CURRENT COVID HOSPITAL CENSUS:
|1216||1293||1197||1356||1351||1304||1300||Lower Rio Grande Valley|
FROM THE ASSOCIATED POST:
1. Health Data: Hospital data related to the coronavirus in the U.S. will now be collected by a private technology firm, rather than the Centers for Disease Control and Prevention. The Trump administration says the move will speed up reporting, and the CDC director said that he’s fine with the change. But some public health leaders fear it will further sideline the agency.
(J. Harris: after a slow start, The Communicable Disease Center (CDC) has become a great source of COVID information and to the coordination of the myriad of agencies and companies and corporations who are fighting the pandemic. It is frightening to me to learn that the white house is redirecting hospital information to some new private firm. I prefer that this hospital information be daily available to the public and to me without non-medical people and politicians fiddling with it. Expletive deleted!).
2. Mask Mandate: Walmart will require customers to wear face coverings at all of its namesake and Sam’s Club stores, making it the largest U.S. retailer to introduce such a policy that has otherwise proven difficult to enforce without state and federal requirements.
COVID IN MEXICO — CURRENT
J Harris: I suspect the true number of cases and deaths is much higher.
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report NEJM
J. Harris: Good news! …The mRNA-1273 vaccine was immunogenic, inducing robust binding antibody responses to both full-length S-2P and receptor-binding domain in all participants after the first vaccination in a time- and dose-dependent fashion. Commensurately high neutralizing antibody responses were also elicited in a dose-dependent fashion. Seroconversion was rapid for binding antibodies, occurring within 2 weeks after the first vaccination, but pseudovirus neutralizing activity was low before the second vaccination, which supports the need for a two-dose vaccination schedule. It is important to note that both binding and neutralizing antibody titers induced by the two-dose schedule were similar to those found in convalescent serum specimens. However, interpretation of the significance of those comparisons must account for the variability in Covid-19 convalescent antibody titers according to factors such as patient age, disease severity, and time since disease onset and for the number of samples in the panel.12,13
In this interim report of follow-up of participants through day 57, we were not able to assess the durability of the immune responses; however, participants will be followed for 1 year after the second vaccination with scheduled blood collections throughout that period to characterize the humoral and cellular immunologic responses. This longitudinal assessment is relevant given that natural history studies suggest that SARS-CoV and MERS-CoV (Middle East respiratory syndrome coronavirus) infections, particularly mild illnesses, may not generate long-lived antibody responses.20-22
….Of the three doses evaluated, the 100-μg dose elicits high neutralization responses and Th1-skewed CD4 T cell responses, coupled with a reactogenicity profile that is more favorable than that of the higher dose. A phase 2 trial of mRNA-1273 in 600 healthy adults, evaluating doses of 50 μg and 100 μg, is ongoing (ClinicalTrials.gov number, NCT04405076. opens in new tab). A large phase 3 efficacy trial, expected to evaluate a 100-μg dose, is anticipated to begin during the summer of 2020.
How does Moses make coffee? Hebrews it.
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