May 26, 2020
“Serologic methods have been developed and will have important public health and clinical uses to monitor and respond to the COVID-19 pandemic.
” Below is my translation of some of this information. I apologize if I have made errors or overly simplified the material. It is all cited above for you through evaluation. JHarris
“…antibody tests help determine whether the individual being tested was ever infected—even if that person never showed symptoms. “…serology (antibody)assays do not typically replace direct detection methods as the primary tool for diagnosing an active SARS-CoV-2 infection, but they do have several important applications in monitoring and responding to the COVID-19 pandemic.’’
• Currently, there is no identified advantage of assays whether they test for IgG, IgM and IgG, or total antibody.
• It is important to minimize false positive test results by choosing an assay with high specificity and by testing populations and individuals with an elevated likelihood of previous exposure to SARS-CoV-2
• Antibodies most commonly become detectable 1-3 weeks after symptom onset, at which time evidence suggests that infectiousness likely is greatly decreased and that some degree of immunity from future infection has developed
• In some instances, serologic test results may assist with identifying persons potentially infected with SARS-CoV-2 and determining who may qualify to donate blood that can be used to manufacture convalescent plasma as a possible treatment for those who are seriously ill from COVID-19.
• In addition, the development of neutralizing antibodies can also be assessed. Neutralizing antibodies inhibit viral replication in vitro, and as with many infectious diseases, their presence correlates with immunity to future infection, at least temporarily. NEW.
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